Pyrazole, 4-methyl-
Fomepizole
CAS: 7554-65-6
Molecular Formula: C4H6N2
Pyrazole, 4-methyl- - Names and Identifiers
| Name | Fomepizole |
| Synonyms | Fomepizole AKOS B014452 4-Methylpyrazol 4-METHYLPYRAZOLE 4-methyl-pyrazol 4-Methylpyrazole 4-METHYLPYRRAZOLE Pyrazole, 4-methyl- 4-Methyl-1H-pyrazole 4-methyl-1H-pyrazole 1H-Pyrazole, 4-methyl- |
| CAS | 7554-65-6 |
| EINECS | 231-445-0 |
| InChI | InChI=1/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6) |
Pyrazole, 4-methyl- - Physico-chemical Properties
| Molecular Formula | C4H6N2 |
| Molar Mass | 82.1 |
| Density | 0.993g/mLat 25°C(lit.) |
| Melting Point | 13°C |
| Boling Point | 99-100°C6mm Hg(lit.) |
| Flash Point | 205°F |
| Water Solubility | soluble |
| Solubility | Methanol |
| Vapor Presure | 7.136-87.85Pa at 20-50℃ |
| Appearance | Colorless liquid or white solid |
| Specific Gravity | 0.993 |
| Color | Clear colorless to yellow |
| Merck | 14,4226 |
| BRN | 105204 |
| pKa | 14.95±0.50(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Hygroscopic |
| Refractive Index | n20/D 1.495(lit.) |
| MDL | MFCD00005245 |
| Physical and Chemical Properties | density 0.993
refractive index 1.493-1.495
flash point 96 ° C
water-soluble
boiling point 99-100 °c (6 mmHg) |
Pyrazole, 4-methyl- - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | 2810 |
| WGK Germany | 3 |
| RTECS | UQ7350000 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29331990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 (7 days) in mice, rats (mmol/kg): 3.8, 3.8 i.v.; 7.8, 6.5 orally (Magnusson) |
Pyrazole, 4-methyl- - Reference
| Reference Show more | 1. Hu Ying also, Prince Jian, Li Deng-ke, Quan Zheng-Yang, Wang Cheng-Yu, Sun Zhen-Xiao. Inhibition of CYP2E1 enhances hepatotoxicity of water extract of Polygonum multiflorum Thunb and screening of its toxic components [J]. Pharmacovigilance in China, 2021,18(03):206-212. 2. [IF = 1.908] Yun-Jing Zhang et al."Evaluation of the effect of Bovis calculation artifact on eight rat cytochrome P450 isozymes using LC-MS/MS and cocktail approach." Xenobiotica. 2021;51(9):1010-1018 3. [IF = 5.811] Jiang XL et al."Patho protective Effect of ooppanax elatus Nakai adentitive Roots Extract by Regulating CYP450 and PPAR Signaling Pathway .." Frontiers in Pharmacology. 2022 May;13:761618-761618 |
Pyrazole, 4-methyl- - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Overview | 4-methylpyrazole is an antidote for methanol and ethylene glycol poisoning, and is a competitive inhibitor of alcohol dehydrogenase, can inhibit the role of dehydrogenase, prevent the dehydrogenation of methanol and ethylene glycol in the body to produce formaldehyde, formic acid or glyoxal, oxalic acid, and thus play a role in detoxification. |
| properties | 4-methylpyrazole is a heterocyclic compound, which is stronger and more specific than ethanol, low toxicity, can replace ethanol as methanol and ethylene glycol poisoning antidote. |
| Related studies | a genotype-specific approach using 4-methylpyrazole to treat human subjects has been reported. |
| biological activity | 4-methylpyrazole (Antizol, Antizol-Vet) is a competitive alcohol dehydrogenase inhibitor. |
| Target | Value |
| Use | an effective antidote for methanol and ethylene glycol poisoning. |
Last Update：2024-04-09 21:11:58
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